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ConclusionĮven when uncertainties are taken into account, we find that diffusion alone is not sufficient to explain transport of tracer deep into the white matter as seen in experimental data. In a model including drainage directly from the brain parenchyma, time to peak occured after 6–8 h for the gray matter. ![]() However, the expected time to peak was reduced to 11 h when an additional directionality was prescribed for the glymphatic circulation. Models of the glymphatic system were similar qualitatively to the models of pure diffusion with respect to expected time to peak but displayed less variability. In models of pure diffusion, the expected amount of tracer in the gray matter reached peak value after 15 h, while the white matter did not reach peak within 24 h with high likelihood. Our results were compared with experimental MRI results of tracer enhancement. 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